Physical activity across the lifespan and liver cancer incidence in the NIH-AARP Diet and Health Study cohort.

ABSTRACT: While liver cancer rates in the United States are increasing, 5-year survival is only 17.6%, underscoring the importance of prevention. Physical activity has been associated with lower risk of developing liver cancer, but most studies assess physical activity only at a single point in time, often in midlife. We utilized physical activity data from 296,661 men and women in the NIH-AARP Diet and Health Study cohort to test whether physical activity patterns over the life course could elucidate the importance of timing of physical activity on liver cancer risk. We used group modeling of longitudinal data to create physical activity trajectories using four time points across the life course from teenage years through middle age, identifying seven distinct trajectories. We then used Cox proport

SUBMITTER: Arem H 

PROVIDER: S-EPMC5911600 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature