Association Between Carotid Artery Function and Structure in the Northern Manhattan Study.

ABSTRACT:

Background and purpose

Carotid plaque (CP), carotid intima media thickness (cIMT), and stiffness (STIFF) are pre-clinical markers of atherosclerosis and predictors of cerebrovascular disease (CVD). We sought to investigate whether STIFF is a significant determinant of cIMT and CP, which may provide an insight into the mechanism by which STIFF adds to the risk of CVD.

Methods

We analyzed 876 stroke-free subjects from the Northern Manhattan Study with available ultrasound measures. To obtain the associations with STIFF, we performed multivariable-adjusted regression, negative binomial regression (for CP number), and multinomial logistic regression (for plaque area).

Results

The mean age was 64 ± 9 years; 63% women and 65% Caribbean Hispanics. The mean cIMT was 0.93 ± 0.

SUBMITTER: Della-Morte D 

PROVIDER: S-EPMC5911635 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature