Pediatric norovirus GII.4 infections in Nicaragua, 1999-2015.

ABSTRACT:

Objectives

Investigate clinical and epidemiological factors of pediatric GII.4 norovirus infections in children with acute gastroenteritis (AGE) in Nicaragua between 1999 and 2015.

Methods

We retrospectively analyzed laboratory and epidemiologic data from 1,790 children≤7years with AGE from 6 hospitals in Nicaragua (n=538), and 3 community clinics (n=919) and households (n=333) in León, between 1999 and 2015. Moreover, asymptomatic children from community clinics (n=162) and households (n=105) were enrolled. Norovirus was detected by real-time PCR and genotyped by sequencing the N-terminal and shell region of the capsid gene.

Results

Norovirus was found in 19% (n=338) and 12% (n=32) of children with and without AGE, respectively. In total, 20 genotypes including a ten

SUBMITTER: Bucardo F 

PROVIDER: S-EPMC5911913 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature