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Transcriptional Repression and Protein Degradation of the Ca²⁺-Activated K⁺ Channel K_Ca1.1 by Androgen Receptor Inhibition in Human Breast Cancer Cells.

ABSTRACT: The large-conductance Ca²⁺-activated K⁺ channel K_Ca1.1 plays an important role in the promotion of breast cancer cell proliferation and metastasis. The androgen receptor (AR) is proposed as a therapeutic target for AR-positive advanced triple-negative breast cancer. We herein investigated the effects of a treatment with antiandrogens on the functional activity, activation kinetics, transcriptional expression, and protein degradation of K_Ca1.1 in human breast cancer MDA-MB-453 cells using real-time PCR, Western blotting, voltage-sensitive dye imaging, and whole-cell patch clamp recording. A treatment with the antiandrogen bicalutamide or enzalutamide for 48 h significantly suppressed (1) depolarization responses induced by paxilline (PAX), a speci

SUBMITTER: Khatun A

PROVIDER: S-EPMC5911984 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Dataset Information

Transcriptional Repression and Protein Degradation of the Ca²⁺-Activated K⁺ Channel K_Ca1.1 by Androgen Receptor Inhibition in Human Breast Cancer Cells.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Transcriptional Repression and Protein Degradation of the Ca2+-Activated K+ Channel KCa1.1 by Androgen Receptor Inhibition in Human Breast Cancer Cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Transcriptional Repression and Protein Degradation of the Ca²⁺-Activated K⁺ Channel K_Ca1.1 by Androgen Receptor Inhibition in Human Breast Cancer Cells.