Ontology highlight
ABSTRACT:
SUBMITTER: Bogdanovic O
PROVIDER: S-EPMC5912259 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nature genetics 20160229 4
The vertebrate body plan and organs are shaped during a conserved embryonic phase called the phylotypic stage. However, the mechanisms that guide the epigenome through this transition and their evolutionary conservation remain elusive. Here we report widespread DNA demethylation of enhancers during the phylotypic period in zebrafish, Xenopus tropicalis and mouse. These enhancers are linked to developmental genes that display coordinated transcriptional and epigenomic changes in the diverse verte ...[more]