Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.

ABSTRACT: Metabolic syndrome (MetS) is a term used to characterize individuals having at least three of the following diseases: obesity, dyslipidemia, hyperglycemia, insulin resistance, hypertension, and nonalcoholic fatty liver disease (NAFLD). It is widespread, and the number of individuals with MetS is increasing. However, the events leading to the manifestation of MetS are not well-understood. Here, we show that loss of murine ARV1 (mARV1) results in resistance to acquiring diseases associated with MetS. Arv1^-/- animals fed a high-fat diet were resistant to diet-induced obesity, had lower blood cholesterol and triglyceride levels, and retained glucose tolerance and insulin sensitivity. Livers showed no gross morphological changes, contained lower levels of cholest

SUBMITTER: Gallo-Ebert C 

PROVIDER: S-EPMC5912475 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature