Mass spectrometric evidence for neuropeptide-amidating enzymes in Caenorhabditis elegans.

ABSTRACT: Neuropeptides constitute a vast and functionally diverse family of neurochemical signaling molecules and are widely involved in the regulation of various physiological processes. The nematode Caenorhabditis elegans is well-suited for the study of neuropeptide biochemistry and function, as neuropeptide biosynthesis enzymes are not essential for C. elegans viability. This permits the study of neuropeptide biosynthesis in mutants lacking certain neuropeptide-processing enzymes. Mass spectrometry has been used to study the effects of proprotein convertase and carboxypeptidase mutations on proteolytic processing of neuropeptide precursors and on the peptidome in C. elegans However, the enzymes required for the last step in the production of many bioactive peptides, the carb

SUBMITTER: Van Bael S 

PROVIDER: S-EPMC5912480 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature