CD103⁺CD11b⁺ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin.

ABSTRACT: Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103⁺CD11b⁺ (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103⁺CD11b^- (SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells accumulating in the

SUBMITTER: Flores-Langarica A 

PROVIDER: S-EPMC5912514 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature