Characterization and evaluation of graphene oxide scaffold for periodontal wound healing of class II furcation defects in dog.

ABSTRACT:

Introduction

The 3-dimensional scaffold plays a key role in volume and quality of repair tissue in periodontal tissue engineering therapy. We fabricated a novel 3D collagen scaffold containing carbon-based 2-dimensional layered material, named graphene oxide (GO). The aim of this study was to characterize and assess GO scaffold for periodontal tissue healing of class II furcation defects in dog.

Materials and methods

GO scaffolds were prepared by coating the surface of a 3D collagen sponge scaffold with GO dispersion. Scaffolds were characterized using cytotoxicity and tissue reactivity tests. In addition, GO scaffold was implanted into dog class II furcation defects and periodontal healing was investigated at 4 weeks postsurgery.

Results

GO scaffold exhibited low cyt

SUBMITTER: Kawamoto K 

PROVIDER: S-EPMC5912619 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature