A longitudinal investigation of cognitive function in children and adolescents with type 1 diabetes mellitus.

ABSTRACT:

Objective

Cross-sectional studies find altered cognition in youth with type 1 diabetes mellitus (T1DM). However, few longitudinal studies have examined the trajectories of their cognitive performance over time. The aims of this study were to explore longitudinal change in cognitive function in youth with T1DM as compared with nondiabetic sibling controls, and how glycemic control and age of onset influence cognitive performance over time.

Methods

We assessed crystallized intelligence, visual-spatial ability, delayed memory, and processing speed at 3 time points using the same cognitive tasks in youth with T1DM and sibling controls. Hierarchical linear modeling examined relationships between diabetes, hyperglycemia (HbA1c values), age of onset, and cognition over 5.5 y.

Re

SUBMITTER: Kirchhoff BA 

PROVIDER: S-EPMC5912686 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature