Open label comparative trial of mono versus dual antibiotic therapy for Typhoid Fever in adults.

ABSTRACT:

Background

Emerging resistance to antibiotics renders therapy of Typhoid Fever (TF) increasingly challenging. The current single-drug regimens exhibit prolonged fever clearance time (FCT), imposing a great burden on both patients and health systems, and potentially contributing to the development of antibiotic resistance and the chronic carriage of the pathogens. The aim of our study was to assess the efficacy of combining third-generation cephalosporin therapy with azithromycin on the outcomes of TF in patients living in an endemic region.

Methods

An open-label, comparative trial was conducted at Dhulikhel Hospital, Nepal, between October 2012 and October 2014. Only culture-confirmed TF cases were eligible. Patients were alternately allocated to one of four study arms: hosp

SUBMITTER: Zmora N 

PROVIDER: S-EPMC5912710 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature