Local and systemic inflammatory lipid profiling in a rat model of osteoarthritis with metabolic dysregulation.

ABSTRACT:

Objective

Bioactive oxidised lipids (oxylipins) are important signalling mediators, capable of modulating the inflammatory state of the joint and anticipated to be of importance in joint homeostasis and status of osteoarthritis. The aim of this study was to quantify oxylipin levels in plasma and synovial fluid from rats with experimentally induced osteoarthritis to investigate the potential role of oxylipins as a marker in the disease process of early osteoarthritis.

Design

Forty rats were randomly allocated to a standard or high-fat diet group. After 12 weeks, local cartilage damage was induced in one knee joint in 14 rats of each diet group. The remaining 6 rats per group served as controls. At week 24, samples were collected. Oxylipin levels were quantified by liquid chro

SUBMITTER: de Visser HM 

PROVIDER: S-EPMC5912715 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature