The Evolving Profile of the Signature Amino Acid Residues in HIV-1 Subtype C Tat.

ABSTRACT: Using several HIV-1 tat exon 1 amino acid sequences available from public databases and additional sequences derived from a southern Indian clinical cohort, we compared the profile of the signature amino acid residues (SAR) between two different time periods, 1986-2004 and 2005-2014. The analysis identified eight positions as signature residues in subtype C Tat and demonstrated a changing pattern at four of these positions between the two periods. At three locations (histidine 29, serine 57, and proline 60), there appears to be a nonuniform negative selection against the SAR. The negative selection appears to be severe, especially against histidine 29 (p < .0001) and moderate against proline 60 (p < .0001). The negative selection against serine 57 is statistically insignificant and appears

SUBMITTER: Aralaguppe SP 

PROVIDER: S-EPMC5912721 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature