RORα-expressing T regulatory cells restrain allergic skin inflammation.

ABSTRACT: Atopic dermatitis is an allergic inflammatory skin disease characterized by the production of the type 2 cytokines in the skin by type 2 innate lymphoid cells (ILC2s) and T helper 2 (T_H2) cells, and tissue eosinophilia. Using two distinct mouse models of atopic dermatitis, we show that expression of retinoid-related orphan receptor α (RORα) in skin-resident T regulatory cells (T_regs) is important for restraining allergic skin inflammation. In both models, targeted deletion of RORα in mouse T_regs led to exaggerated eosinophilia driven by interleukin-5 (IL-5) production by ILC2s and T_H2 cells. Expression of RORα in skin-resident T_regs suppressed IL-4 expression and enhanced expression of death receptor 3 (DR3), which is the receptor for

SUBMITTER: Malhotra N 

PROVIDER: S-EPMC5912895 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature