Allostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study.

ABSTRACT: The allostatic load index quantifies the cumulative multisystem physiological response to chronic everyday stress, and includes cardiovascular, metabolic and inflammatory measures. Despite its central role in the stress response, research of the effect of allostatic load on the ageing brain has been limited. We investigated the relation of mid-life allostatic load index and multifactorial predictors of stroke (Framingham stroke risk) and diabetes (metabolic syndrome) with voxelwise structural grey and white matter brain integrity measures in the ageing Whitehall II cohort (N = 349, mean age = 69.6 (SD 5.2) years, N (male) = 281 (80.5%), mean follow-up before scan = 21.4 (SD 0.82) years). Higher levels of all three markers were significantly associated with lower grey matter density. Only h

SUBMITTER: Zsoldos E 

PROVIDER: S-EPMC5913085 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature