The relationship between dopamine receptor blockade and cognitive performance in schizophrenia: a [¹¹C]-raclopride PET study with aripiprazole.

ABSTRACT: Aripiprazole's effects on cognitive function in patients with schizophrenia are unclear because of the difficulty in disentangling specific effects on cognitive function from secondary effects due to the improvement in other schizophrenic symptoms. One approach to address this is to use an intermediate biomarker to investigate the relationship between the drug's effect on the brain and change in cognitive function. This study aims to investigate aripiprazole's effect on working memory by determining the correlation between dopamine D2/3 (D2/3) receptor occupancy and working memory of patients with schizophrenia. Seven patients with schizophrenia participated in the study. Serial positron emission tomography (PET) scans with [¹¹C]raclopride were conducted at 2, 26, and 74 h after

SUBMITTER: Shin S 

PROVIDER: S-EPMC5913226 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature