A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation.

ABSTRACT: Endocytosis of surface receptors and their polarized recycling back to the plasma membrane are central to many cellular processes, such as cell migration, cytokinesis, basolateral polarity of epithelial cells and T cell activation. Little is known about the mechanisms that control the organization of recycling endosomes and how they connect to receptor endocytosis. Here, we follow the endocytic journey of the T cell receptor (TCR), from internalization at the plasma membrane to recycling back to the immunological synapse. We show that TCR triggering leads to its rapid uptake through a clathrin-independent pathway. Immediately after internalization, TCR is incorporated into a mobile and long-lived endocytic network demarked by the membrane-organizing proteins flotillins. Although flotillins

SUBMITTER: Compeer EB 

PROVIDER: S-EPMC5913236 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature