Low-frequency and rare variants may contribute to elucidate the genetics of major depressive disorder.

ABSTRACT: Major depressive disorder (MDD) is a common but serious psychiatric disorder with significant levels of morbidity and mortality. Recent genome-wide association studies (GWAS) on common variants increase our understanding of MDD; however, the underlying genetic basis remains largely unknown. Many studies have been proposed to explore the genetics of complex diseases from a viewpoint of the "missing heritability" by considering low-frequency and rare variants, copy-number variations, and other types of genetic variants. Here we developed a novel computational and statistical strategy to investigate the "missing heritability" of MDD. We applied Hamming distance on common, low-frequency, and rare single-nucleotide polymorphism (SNP) sets to measure genetic distance between two individuals, and

SUBMITTER: Yu C 

PROVIDER: S-EPMC5913271 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature