On the role of the prefrontal cortex in fatigue effects on cognitive flexibility - a system neurophysiological approach.

ABSTRACT: Demanding tasks like cognitive flexibility show time-related deterioration of performance (i.e. fatigability effects). Fatigability has been associated with structural and functional properties of the prefrontal cortex. However, the electrophysiological underpinnings of these processes are not well understood. We examined n = 34 healthy participants with a task switching paradigm in which switches were either signaled by cues or needed to be maintained by working memory processes. We analyzed event-related potentials (ERPs) and performed residue iteration decomposition (RIDE) to account for effects of fatigue on intra-individual variability of neurophysiological data. This was combined with source localization methods. We show that task switching is affected by time on task (TOT) effects m

SUBMITTER: Petruo VA 

PROVIDER: S-EPMC5913330 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature