Proportion of contextual effects in the treatment of fibromyalgia-a meta-analysis of randomised controlled trials.

ABSTRACT: The objective of this study is to examine the proportion of the total treatment effect that is attributable to contextual effects in randomised controlled trials (RCTs) of treatments for fibromyalgia. A systematic literature search was undertaken in Medline, Web of Science, EMBASE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Allied and Complementary Medicine in September 2015. The proportion of contextual effect (PCE) was calculated by dividing the improvement in the placebo arm by the improvement in the treatment arm. The measure was log-transformed for each trial and the random effects model was used to pool data. The primary outcome was pain. Secondary outcomes were fibromyalgia impact questionnaire (FIQ) total and fatigue. Heterogeneity was quantified using I

SUBMITTER: Whiteside N 

PROVIDER: S-EPMC5913391 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature