Clinical significance of CD73 in triple-negative breast cancer: multiplex analysis of a phase III clinical trial.

ABSTRACT:

Background

CD73 is an ecto-enzyme that promotes tumor immune escape through the production of immunosuppressive extracellular adenosine in the tumor microenvironment. Several CD73 inhibitors and adenosine receptor antagonists are being evaluated in phase I clinical trials.

Patients and methods

Full-face sections from formalin-fixed paraffin-embedded primary breast tumors from 122 samples of triple-negative breast cancer (TNBC) from the BIG 02-98 adjuvant phase III clinical trial were included in our analysis. Using multiplex immunofluorescence and image analysis, we assessed CD73 protein expression on tumor cells, tumor-infiltrating leukocytes and stromal cells. We investigated the associations between CD73 protein expression with disease-free survival (DFS), overall surviva

SUBMITTER: Buisseret L 

PROVIDER: S-EPMC5913595 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature