Beyond second-line therapy in patients with metastatic colorectal cancer: a systematic review.

ABSTRACT:

Background

The optimal chemotherapeutic regimen for use beyond the second line for patients with metastatic colorectal cancer (mCRC) remains unclear.

Materials and methods

We systematically searched the Cochrane Database of Systematic Reviews, EMBASE and Medline for records published between January 2002 and May 2017, and cancer congress databases for records published between January 2014 and June 2017. Eligible studies evaluated the efficacy, safety and patient-reported outcomes of monotherapies or combination therapies at any dose and number of treatment cycles for use beyond the second line in patients with mCRC. Studies were assessed for design and quality, and a qualitative data synthesis was conducted to understand the impact of treatment on overall survival and other

SUBMITTER: Arnold D 

PROVIDER: S-EPMC5913602 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature