A Persistent Hotspot of Schistosoma mansoni Infection in a Five-Year Randomized Trial of Praziquantel Preventative Chemotherapy Strategies.

ABSTRACT:

Background

Persistent hotspots have been described after mass drug administration (MDA) for the control of schistosomiasis, but they have not been studied during the course of a multiyear MDA program.

Methods

In data from a 5-year study of school-based and village-wide preventive chemotherapy strategies for Schistosoma mansoni, spatial scan statistics were used to find infection hotspots in 3 populations: 5- to 8-year-olds, 9- to 12-year-olds, and adults. Negative binomial regression was used to analyze changes from baseline, and receiver operating characteristic analyses were used to predict which villages would reach prevalence and intensity endpoints.

Results

We identified a persistent hotspot, not associated with study arm, where S. mansoni infection prevalence an

SUBMITTER: Wiegand RE 

PROVIDER: S-EPMC5913648 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature