Family history of gastric mucosal abnormality and the risk of gastric cancer: a population-based observational study.

ABSTRACT:

Background

An increased prevalence of gastric premalignant abnormalities was reported among relatives of gastric cancer (GC) patients, with rather unexplored clinical significance.

Methods

In Swedish computerized pathology registers, we identified, as 'index' persons, 232 681 patients who were born after 1931 and underwent endoscopic examination with stomach biopsy between 1979 and 2014. Through linkage with the Multi-Generation Register, we compiled a cohort consisting of 903 337 first-degree relatives of these biopsied patients. The relatives were grouped according to their 'family histories', defined as the first gastric mucosal diagnosis of the index person or GC family history known before that. Standardized incidence ratios (SIRs) provided comparisons with the matched

SUBMITTER: Song H 

PROVIDER: S-EPMC5913654 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature