Rates of Mutation and Recombination in Siphoviridae Phage Genome Evolution over Three Decades.

ABSTRACT: The evolution of asexual organisms is driven not only by the inheritance of genetic modification but also by the acquisition of foreign DNA. The contribution of vertical and horizontal processes to genome evolution depends on their rates per year and is quantified by the ratio of recombination to mutation. These rates have been estimated for bacteria; however, no estimates have been reported for phages. Here, we delineate the contribution of mutation and recombination to dsDNA phage genome evolution. We analyzed 34 isolates of the 936 group of Siphoviridae phages using a Lactococcus lactis strain from a single dairy over 29 years. We estimate a constant substitution rate of 1.9 × 10-4 substitutions per site per year due to mutation that is within the range of estimates for eukaryotic RNA a

SUBMITTER: Kupczok A 

PROVIDER: S-EPMC5913663 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature