Prostaglandin E₂ Induction Suppresses the Th1 Immune Responses in Cattle with Johne's Disease.

ABSTRACT: Johne's disease, caused by Mycobacterium avium subsp. paratuberculosis, is a bovine chronic infection that is endemic in Japan and many other countries. The expression of immunoinhibitory molecules is upregulated in cattle with Johne's disease, but the mechanism of immunosuppression is poorly understood. Prostaglandin E₂ (PGE₂) is immunosuppressive in humans, but few veterinary data are available. In this study, functional and kinetic analyses of PGE₂ were performed to investigate the immunosuppressive effect of PGE₂ during Johne's disease. In vitro PGE₂ treatment decreased T-cell proliferation and Th1 cytokine production and upregulated the expression of immunoinhibitory molecules such as interleukin-10 and progra

SUBMITTER: Sajiki Y 

PROVIDER: S-EPMC5913856 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature