Pterostilbene, a Potential MCR-1 Inhibitor That Enhances the Efficacy of Polymyxin B.

ABSTRACT: We characterized the synergistic effect produced between pterostilbene and polymyxin B (fractional inhibitory concentration [FIC] index = 0.156 or 0.188) against MCR-producing Escherichia coli strains of both human and animal origins. The time-killing assays showed that either pterostilbene or polymyxin B failed to eradicate the mcr-1- and NDM-positive E. coli strain ZJ487, but the combination eliminated the strain by 1 h postinoculation. The survival rate of mice after intraperitoneal infections was significantly enhanced from 0% to 60% in the group in which combination therapy was applied.

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC5913934 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature