Population Pharmacokinetics of High-Dose Tigecycline in Patients with Sepsis or Septic Shock.

ABSTRACT: Tigecycline is a glycylcycline often used in critically ill patients as the antibiotic of last resort. The pharmacokinetics (PK) of tigecycline in intensive care unit (ICU) patients can be affected by severe pathophysiological changes so that standard dosing might not be adequate. The aim of this study was to describe population PK of high-dose tigecycline in patients with sepsis or septic shock and evaluate the relationship between individual PK parameters and patient covariates. The study population consisted of 37 adult ICU patients receiving a 200-mg loading dose of tigecycline followed by multiple doses of 100 mg every 12 h. Blood samples were collected at 0.5, 2, 4, 8, and 12 h after dose administration. A two-compartment model with interindividual (IIV) and interoccasion (IOV) varia

SUBMITTER: Borsuk-De Moor A 

PROVIDER: S-EPMC5913959 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature