In Vivo Transfer and Microevolution of Avian Native IncA/C₂bla_NDM-1-Carrying Plasmid pRH-1238 during a Broiler Chicken Infection Study.

ABSTRACT: The emergence and spread of carbapenemase-producing Enterobacteriaceae (CPE) in wildlife and livestock animals pose an important safety concern for public health. With our in vivo broiler chicken infection study, we investigated the transfer and experimental microevolution of the bla_NDM-1-carrying IncA/C₂ plasmid (pRH-1238) introduced by avian native Salmonella enterica subsp. enterica serovar Corvallis without inducing antibiotic selection pressure. We evaluated the dependency of the time point of inoculation on donor (S Corvallis [12-SA01738]) and plasmid-free Salmonella recipient [d-tartrate-fermenting (d-Ta⁺) S Paratyphi B (13-SA01617), referred to here as S Paratyphi B (d-Ta⁺)] e

SUBMITTER: Hadziabdic S 

PROVIDER: S-EPMC5913973 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature