N-of-1 trials in the clinical care of patients in developing countries: a systematic review.

ABSTRACT:

Background

N-of-1 trials have a potential role in promoting patient-centered medicine in developing countries. However, there is limited academic literature regarding the use of N-of-1 trials in the clinical care of patients in resource-poor settings.

Objective

To assess the extent of use, purpose and treatment outcome of N-of-1 trials in developing countries.

Method

A systematic review of clinical N-of-1 trials was conducted between 1985 and September 2015 using PubMed, Embase, CINAHL, Web of Science and the Cochrane Central Register of Controlled Trials. Grey literature databases and clinical trial registers were also searched. This review included randomized, multi-cycle, crossover within individual patient trials involving drug intervention. Quality assessment and

SUBMITTER: Alemayehu C 

PROVIDER: S-EPMC5914018 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature