Polygenic Risk, Appetite Traits, and Weight Gain in Middle Childhood: A Longitudinal Study.

ABSTRACT:

Importance

Genome-wide association studies have identified genetic risks for obesity. These genetic risks influence development of obesity partly by accelerating weight gain in childhood. Research is needed to identify mechanisms to inform intervention. Cross-sectional studies suggest appetite traits as a candidate mechanism. Longitudinal studies are needed to test whether appetite traits mediate genetic influences on children's weight gain.

Objective

To test whether genetic risk for obesity predicts accelerated weight gain in middle childhood (ages 4-8 years) and whether genetic association with accelerated weight gain is mediated by appetite traits.

Design, setting, and participants

Longitudinal study of a representative birth cohort at the Trondheim Early Secure St

SUBMITTER: Steinsbekk S 

PROVIDER: S-EPMC5914161 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature