Sustained-release synthetic biomarkers for monitoring thrombosis and inflammation using point-of-care compatible readouts.

ABSTRACT: Postoperative infection and thromboembolism represent significant sources of morbidity and mortality but cannot be easily tracked after hospital discharge. Therefore, a molecular test that could be performed at home would significantly impact disease management. Our lab has previously developed intravenously delivered 'synthetic biomarkers' that respond to dysregulated proteases to produce a urinary signal. These assays, however, have been limited to chronic diseases or acute diseases initiated at the time of diagnostic administration. Here, we formulate a subcutaneously administered sustained release system by using small PEG scaffolds (<10 nm) to promote diffusion into the bloodstream over a day. We demonstrate the utility of a thrombin sensor to identify thrombosis and an MMP sensor to

SUBMITTER: Dudani JS 

PROVIDER: S-EPMC5914179 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature