A preliminary study of association of genetic variants with early response to olanzapine in schizophrenia.

ABSTRACT:

Background

Treatment response can be predicted in schizophrenia by DNA information in the drug metabolism pathways. This study aimed to examine clinical characteristics and genetic determinant (s) of early response to olanzapine treatment in schizophrenia using specified drug metabolizing genes.

Materials and methods

Consenting participants (n = 33) suffering from schizophrenia were diagnosed on Diagnostic Interview for Genetic Studies. Oral olanzapine was administered in an incremental dose up to 10 mg (2 weeks) and 20 mg (6 weeks). All participants were tested on Positive and Negative Syndrome Scale, Clinical Global Impressions, and Global Assessment of Functioning at 0, 2, and 6 weeks. Side effects were also evaluated. After 2 weeks, 11 (33.33%) fulfilled criteria

SUBMITTER: Singh A 

PROVIDER: S-EPMC5914236 | biostudies-literature | 2018 Jan-Mar

REPOSITORIES: biostudies-literature