Role of DiGeorge syndrome critical region gene 9, a long noncoding RNA, in gastric cancer.

ABSTRACT:

Introduction

Long non-coding RNAs (lncRNAs) regulate and influence cancer cell development and tumor formation. However, the role for lncRNAs in gastric cancer has not been fully established. In this study, DGCR9, a lncRNA, was significantly upregulated in gastric cancer cell lines.

Methods

The expression levels of DGCR9 in each patient between formalin-fixed, paraffin-embedded (FFPE) gastric cancer tissues and adjacent noncancer tissues (NAT) (n=102) were measured by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). The effect of DGCR9 on cellular proliferation, migration, and glucose uptake was investigated in vitro, respectively.

Results

DGCR9 was shown to have increased expression in gastric cancer tissues and in g

SUBMITTER: Ni C 

PROVIDER: S-EPMC5914736 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature