Drosophila PEBP1 inhibits intestinal stem cell aging via suppression of ERK pathway.

ABSTRACT: The intestine is a high cellular turnover tissue largely dependent on the regenerative function of stem cell throughout life, and a signaling center for the health and viability of organisms. Therefore, better understanding of the mechanisms underlying the regulation of intestinal stem cell (ISC) regenerative potential is essential for the possible intervention of aging process and age-related diseases. Drosophila midgut is a well-established model system for studying the mechanisms underlying ISC regenerative potential during aging. Here, we report the requirement of Drosophila phosphatidylethanolamine binding protein 1 (PEBP1) in ISC regenerative potential. We showed that PEBP1 was strongly expressed in enterocytes (ECs) of guts and its decrease with age and oxidative stres

SUBMITTER: Pyo JH 

PROVIDER: S-EPMC5915051 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature