A drug combination targeting hypoxia induced chemoresistance and stemness in glioma cells.

ABSTRACT: Hypoxia is a characteristic of solid tumors especially Glioblastoma and is critical to chemoresistance. Cancer stem cells present in hypoxic niches are known to be a major cause of the progression, metastasis and relapse. We tried to identify synergistic combinations of drugs effective in both hypoxia and normoxia in tumor cells as well as in cancer stem cells. Since COX-2 is over-expressed in subset of glioblastoma and is also induced in hypoxia, we studied combinations of a prototype Cyclooxygenase (COX-2) inhibitor, NS-398 with various drugs (BCNU, Temozolomide, 2-Deoxy-D-glucose and Cisplatin) for their ability to abrogate chemoresistance under both severe hypoxia (0.2% O₂) and normoxia (20% O₂) in glioma cells. The only effective combination was of NS-398 and BCN

SUBMITTER: Jalota A 

PROVIDER: S-EPMC5915077 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature