Enhanced intratumoral expression of RNF2 is a favorable prognostic factor for patients with cutaneous melanoma?

ABSTRACT: Recent studies involving melanoma cell lines suggest that enhanced expression of epigenetic regulator RNF2 supports proliferation and promotes metastasis. However, it is not clear to what extent those data apply to disease progression and prognosis for melanoma patients. Therefore the aim of the present study was to assess the prognostic power of RNF2 intratumoral expression by melanoma cells. RNF2 was detected immunohistochemically in standard formalin-fixed paraffin-embedded samples of 9 benign nevi, 60 melanomas and 24 nodal metastases. The lowest percentage of RNF2-positive melanocytes found in nevi was comparable to expression levels in normal skin. The RNF2 expression found in melanomas was significantly higher and it was even more enhanced in metastases. The increased occurrence of

SUBMITTER: Kuzbicki L 

PROVIDER: S-EPMC5915146 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature