Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder.

ABSTRACT:

Background

Maternal folic acid (FA) protects against developmental toxicity from certain environmental chemicals.

Objective

We examined combined exposures to maternal FA and pesticides in relation to autism spectrum disorder (ASD).

Methods

Participants were California children born from 2000-2007 who were enrolled in the Childhood Autism Risks from Genetics and the Environment (CHARGE) case-control study at age 2-5 y, were clinically confirmed to have ASD (n=296) or typical development (n=220), and had information on maternal supplemental FA and pesticide exposures. Maternal supplemental FA and household pesticide product use were retrospectively collected in telephone interviews from 2003-2011. High vs. low daily FA intake was dichotomized at 800μg (median). Mothers'

SUBMITTER: Schmidt RJ 

PROVIDER: S-EPMC5915192 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature