Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population.

ABSTRACT:

Background

Rice contains arsenic, a known skin carcinogen. Rice intake has been associated with arsenic-related skin lesions in South Asia, but its association with skin cancers is as yet unknown.

Objectives

We aimed to investigate whether rice intake contributes to urinary arsenic concentration and risk of squamous cell carcinoma (SCC) of the skin in a U.S. population.

Methods

Rice consumption was assessed using a food frequency questionnaire administered as part of a population-based case-control study of 487 SCC cases and 462 age- and gender-matched controls. Arsenic concentration in household tap water and urine samples were measured using inductively coupled mass spectrometry (ICP-MS) and high-resolution ICP-MS, respectively. Odds ratios (OR) for SCC associated w

SUBMITTER: Gossai A 

PROVIDER: S-EPMC5915202 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature