Genetically elevated gamma-glutamyltransferase and Alzheimer's disease.

ABSTRACT: Observational epidemiological evidence supports a linear and independent association between serum gamma-glutamyltransferase (GGT) concentrations and the risk of Alzheimer's disease (AD). However, the causality of this association has not been previously investigated. We sought to assess the causal nature of this association using a Mendelian randomization (MR) approach. Using inverse-variance weighted MR analysis, we assessed the association between GGT and AD using summary statistics for single nucleotide polymorphism (SNP)-AD associations obtained from the International Genomics of Alzheimer's Project of 17,008 individuals with AD and 37,154 controls. We used 26 SNPs significantly associated with GGT in a previous genome-wide association study on liver enzymes as instruments. Sensitivit

SUBMITTER: Kunutsor SK 

PROVIDER: S-EPMC5915296 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature