Analysis of immune-related genes during Nora virus infection of Drosophila melanogaster using next generation sequencing.

ABSTRACT: Drosophila melanogaster depends upon the innate immune system to regulate and combat viral infection. This is a complex, yet widely conserved process that involves a number of immune pathways and gene interactions. In addition, expression of genes involved in immunity are differentially regulated as the organism ages. This is particularly true for viruses that demonstrate chronic infection, as is seen with Nora virus. Nora virus is a persistent non-pathogenic virus that replicates in a horizontal manner in D. melanogaster. The genes involved in the regulation of the immune response to Nora virus infection are largely unknown. In addition, the temporal response of immune response genes as a result of infection has not been examined. In this study, D. melanogaster either

SUBMITTER: Lopez W 

PROVIDER: S-EPMC5915338 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature