Increased functional connectivity of the posterior cingulate cortex with the lateral orbitofrontal cortex in depression.

ABSTRACT: To analyze the functioning of the posterior cingulate cortex (PCC) in depression, we performed the first fully voxel-level resting state functional-connectivity neuroimaging analysis of depression of the PCC, with 336 patients with major depressive disorder and 350 controls. Voxels in the PCC had significantly increased functional connectivity with the lateral orbitofrontal cortex, a region implicated in non-reward and which is thereby implicated in depression. In patients receiving medication, the functional connectivity between the lateral orbitofrontal cortex and PCC was decreased back towards that in the controls. In the 350 controls, it was shown that the PCC has high functional connectivity with the parahippocampal regions which are involved in memory. The findings support the theory

SUBMITTER: Cheng W 

PROVIDER: S-EPMC5915597 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature