PlGF enhances TLR-dependent inflammatory responses in human mononuclear phagocytes.

ABSTRACT:

Problem

Levels of placental growth factor (PlGF) peak during third trimester of pregnancy, a time when women are at increased risk of virus-induced morbidity. We hypothesized PlGF might contribute to an exaggerated inflammatory response to Toll-like receptor (TLR) activation.

Method of study

Primary human adult and cord blood CD14⁺ cells were cultured in the presence of TLR ligands and/or PlGF.

Results

PlGF significantly enhanced the magnitude and duration of TNF messenger RNA and protein production by TLR-7/8-activated monocytes, and increased subsequent production of TNF-independent inflammatory cytokines. This PlGF/TLR effect involved multiple inflammatory cytokines/chemokines and was seen with the majority of TLR agonists. PlGF enhanced phosphorylation

SUBMITTER: Newell LF 

PROVIDER: S-EPMC5915625 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature