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Copper-catalyzed formylation of alkenyl C-H bonds using BrCHCl₂ as a stoichiometric formylating reagent.

ABSTRACT: The first example of copper-catalyzed direct formylation of alkenyl C-H bonds for the facile synthesis of α,β-unsaturated aldehydes has been developed. This transformation has demonstrated high reactivity, mild reaction conditions and a broad substrate scope. BrCHCl₂ is expected to be developed as an efficient stoichiometric C1 building block in organic synthesis.

SUBMITTER: Bao Y

PROVIDER: S-EPMC5915796 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Copper-catalyzed formylation of alkenyl C-H bonds using BrCHCl2 as a stoichiometric formylating reagent.

Bao Yan Y Wang Gao-Yin GY Zhang Ya-Xuan YX Bian Kang-Jie KJ Wang Xi-Sheng XS

Chemical science 20180214 11

The first example of copper-catalyzed direct formylation of alkenyl C-H bonds for the facile synthesis of α,β-unsaturated aldehydes has been developed. This transformation has demonstrated high reactivity, mild reaction conditions and a broad substrate scope. BrCHCl2 is expected to be developed as an efficient stoichiometric C1 building block in organic synthesis. ...[more]

PMID: 29732081

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