Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4⁺ T Cell Polarization.

ABSTRACT: Mouse models of lupus have shown that multiple immune cell types contribute to autoimmune disease. This study sought to investigate the involvement of B cells and dendritic cells in supporting the expansion of inflammatory and regulatory CD4⁺ T cells that are critical for lupus pathogenesis. We used lupus-prone B6.NZM2410.Sle1.Sle2.Sle3 (TC) and congenic C57BL/6J (B6) control mice to investigate how the genetic predisposition of these two cell types controls the activity of normal B6 T cells. Using an allogeneic in vitro assay, we showed that TC B1-a and conventional B cells expanded Th17 cells significantly more than their B6 counterparts. This expansion was dependent on CD86 and IL-6 expression and mapped to the Sle1 lupus-susceptibility locus. In vivo, TC B cells promo

SUBMITTER: Choi SC 

PROVIDER: S-EPMC5915918 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature