Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage.

ABSTRACT:

Background and purpose

Intracerebral hemorrhage (ICH) is a devastating disease with a 30-day mortality of ~50%. There are no effective therapies for ICH. ICH results in brain damage in 2 major ways: through the mechanical forces of extravasated blood and then through toxicity of the intraparenchymal blood components including hemoglobin/iron. LTF (lactoferrin) is an iron-binding protein, uniquely abundant in polymorphonuclear neutrophils (PMNs). After ICH, circulating blood PMNs enter the ICH-afflicted brain where they release LTF. By virtue of sequestrating iron, LTF may contribute to hematoma detoxification.

Methods

ICH in mice was produced using intrastriatal autologous blood injection. PMNs were depleted with intraperitoneal administration of anti-Ly-6G antibody. Treatme

SUBMITTER: Zhao X 

PROVIDER: S-EPMC5915919 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature