Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks.

ABSTRACT: Adrenal glucocorticoids (GCs) control a wide range of physiological processes, including metabolism, cardiovascular and pulmonary activities, immune and inflammatory responses, and various brain functions. During stress responses, GCs are secreted through activation of the hypothalamic-pituitary-adrenal axis, whereas circulating GC levels in unstressed states follow a robust circadian oscillation with a peak around the onset of the active period of a day. A recent advance in chronobiological research has revealed that multiple regulatory mechanisms, along with classical neuroendocrine regulation, underlie this GC circadian rhythm. The hierarchically organized circadian system, with a central pacemaker in the suprachiasmatic nucleus of the hypothalamus and local oscillators in peripheral ti

SUBMITTER: Son GH 

PROVIDER: S-EPMC5915959 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature