Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD.

ABSTRACT: Slow immune reconstitution is a major obstacle to the successful use of allogeneic hematopoietic cell transplantation (allo-HCT). As matched sibling donor (MSD) allo-HCT is regarded as the gold standard, we evaluated the pace of immune reconstitution in 157 adult recipients of reduced-intensity conditioning followed by MSD peripheral blood HCT (n = 68) and compared these to recipients of umbilical cord blood (UCB; n = 89). At day 28, UCB recipients had fewer natural killer (NK) cells than MSD recipients, but thereafter, NK cell numbers (and their subsets) were higher in UCB recipients. During the first 6 months to 1 year after transplant, UCB recipients had slower T-cell subset recovery, with lower numbers of CD3⁺, CD8⁺, CD8⁺ naive, CD4⁺ naive, C

SUBMITTER: Bejanyan N 

PROVIDER: S-EPMC5916001 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature