Associations Between Weight Loss, Kidney Function Decline, and Risk of ESRD in the Chronic Kidney Disease in Children (CKiD) Cohort Study.

ABSTRACT:

Background

Anorexia and malnutrition are associated with poor outcomes in children with chronic kidney disease (CKD).

Study design

Observational cohort study.

Setting & participants

We assessed changes in body mass index (BMI) as kidney function declines and its association with risk for end-stage renal disease (ESRD) among 854 participants followed between 2005 to 2013 in the CKD in Children (CKiD) Study.

Predictors

Repeated measurements of estimated glomerular filtration rate (eGFR) by serum creatinine concentration in our trajectory analysis using mixed models; change in BMI z score (per year) after eGFR decreased to <35mL/min/1.73m² in logistic regression models.

Outcomes

Repeated measurements of BMI z score (as a reflection of weight stat

SUBMITTER: Ku E 

PROVIDER: S-EPMC5916028 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature