Branched Chain Amino Acids, Androgen Hormones, and Metabolic Risk Across Early Adolescence: A Prospective Study in Project Viva.

ABSTRACT:

Objective

This study aimed to examine the associations of two obesity-related metabolite patterns with changes in metabolic biomarkers during early adolescence.

Methods

Multivariable linear regression was used to examine associations of branched chain amino acid (BCAA) and androgen hormone patterns with changes in glycemia (fasting glucose, insulin, homeostatic model assessment of insulin resistance), adipokines (leptin, adiponectin), inflammation (C-reactive protein, interleukin-6), lipid profile, and blood pressure during ∼5 years of follow-up among 213 children aged 6 to 10 years at baseline. Covariates included baseline age, pubertal status, biomarker level, and BMI percentile, and age at follow-up. Interactions with sex and baseline BMI percentile were also considered.<

SUBMITTER: Perng W 

PROVIDER: S-EPMC5916029 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature